Sentence examples for titrating out from inspiring English sources

A possible mechanism for the suppression of tumors by 3'UTR is its effect on tumoral gene expression via titrating out the regulating miRNA [14].

We hypothesised therefore, that in over-expressing DG we are potentially titrating out factors such as Tks5 that are crucial to podosome formation.

Recently, de Gier and coworkers observed that overexpressed native SRP substrates accumulate in the cytoplasm by titrating out targeting components (e.g. SRP and FtsY); these 'overflow' substrates become susceptible to degradation and inclusion body formation in the cytoplasm [34].

Interestingly, the addition of the stem-loop RNA sequence to in vitro splicing reactions enhanced IDX inclusion [8], suggesting that the reaction can be activated by titrating out inhibitory factors that recognize this structure.

To support this, when AntiMicA RNA is overexpressed in a wildtype background, R3 accumulation is >70% reduced compared to control (cv Fig. 2 lane 6 vs lane 4) although Anti-MicA overexpression is only about 80% efficient in titrating out MicA [18].

Based on these results, we speculate that the mutant dTip60E431Q protein may produce its dominant negative effect in the fly by outcompeting endogenous wild-type dTip60 for recruitment to chromatin when over-expressed, thus titrating out endogenous histone H4 chromatin acetylation, with resultant deleterious effects on gene expression.

Thus, level of cellular uptake in embryonic cells might be not sufficient to ensure a high enough level of the drug within cells or, alternatively, the drug might be titrated out by the high endogenous FKBP12 level existing in embryos that could also, moreover, compete out the FKBP-linked Cre moiety ([42]; personal observations).

When boundary cells lack Notch activity, either by mutation or by expression of a dominant negative form of Delta known to titrate out the Notch receptor, these cells start to express target genes of Wg (Figures 3E and 3F, and also Figure S1).

In the presence of excess dystroglycan, for example when DG is over-expressed, DG can still be phosphorylated by Src, but the excess DG in the cell effectively titrates out the Src signal with respect to Tks5 levels, thus reducing Tks5 phosphorylation and inhibiting podosome formation.

Alternatively, ERS1 may partially titrate out available RTE1, which promotes ETR1 signaling.

In each case, the mRNA would occupy, or titrate out, a different number of ribosomes.