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Backonja et al. investigated the effect of gabapentin monotherapy on pain associated with diabetic peripheral neuropathy by titrating from 900 to 3600 mg per day or maximum tolerated dosage or placebo [ 12].
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These two studies (powered 65%) were identical parallel group, double-blind, forced-titration active- and placebo-controlled studies comparing duloxetine titrated from 20 mg to 60 mg BID with placebo over 8 weeks of acute treatment.
The difference between the studies might be explained by the slower titration of duloxetine in the first study, in which duloxetine was titrated from a starting dose of 20 mg QD to 60 mg BID over 2 weeks.
Maternal inspired oxygen fraction was titrated from 21%to3%3%.
Blood flow was titrated from 250 to 1000 ml/min.
When the C-cloth is titrated from pHs of 14 to 2, the CV current profile shrinks (with a concomitant decrease in charge-storage capacity).
The dosage was titrated from 25 mg to 400 mg for a period of 1-1.5 months until a therapeutic effect was attained.
Carvedilol was titrated from 3.25 mg per day and metoprolol was titrated from 12.5 mg per day to maximal tolerable doses.
During ER stress, BiP is competitively titrated from the luminal domain of PERK by the excess of unfolded proteins [9].
Neutralizing antibodies were titrated from serum samples collected week 5 and 7 post-vaccination and day 14 post-challenge.
Starting material was standardized across all reactions (0.1 ng eluted DNA), excluding inputs, which were titrated from 0.5 ng to 10 ng per reaction.
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