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All positive samples will be fully titrated to reduce the chance of treatment in false positives.
The dose of morpholino for each gene was initially titrated to reduce lethality at early stages of development (not shown).
On the contrary, the initiation of insulin in individuals with type 2 diabetes, even if it is not titrated to reduce blood glucose levels, was found to reduce β-cell stress and improve the conversion rate of IP [ 11, 12].
Zhang et al. 10 studied the effects of chronic vagal stimulation delivered at a frequency of 20 Hz, a duty cycle of 14 s on and 12 s off, and an intensity individually titrated to reduce sinus rate by approximately 20% in a canine model of HF induced by high-rate ventricular pacing.
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8 Adding insulin to the treatment regimen early is a key factor in good diabetes management since insulin is the most effective agent at reducing glycemia and doses can be titrated to target.
Both approaches were first titrated to determine an effective dose of the inhibitor or morpholino that would reduce cathepsin K activity to levels comparable with WT (see Methods and supplementary material Fig. S4 for details of this titration).
In this model of elastase-induced emphysema, PSV titrated to reach protective tidal volume, compared to PCV, improved lung mechanics, reduced lung hyperinflation and cardiovascular dysfunction, as well as prevented ventilator induced lung injury.
Our simulations predict the use of alternative buffers with a pK of 7.1 7.2 and titrated to a pHe of 7.4 would have negligible effects on blood pHe while reducing tumour acidity.
Treatment with EQW reduced A1C and postprandial glucose to a statistically greater extent than IG titrated to target.
Dopamine dosages are titrated to the severely depleted dorsal striatum (DS).
The drugs are titrated to achieve a 25% reduction of diastolic aortic pressure.
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