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The drug was slowly titrated over 4 weeks to 24 mg or the maximum tolerated dose showing moderate adverse effects (somnolence, dizziness, dry mouth, asthenia) [235, 236].
Twenty patients (11 women; mean age of 62.2 ± 12.7 years, mean ET duration of 25.5 ± 14.9 years) with ET were randomized for treatment with PGB (150 600 mg/day) or placebo, titrated over 6 weeks.
The other Class I, randomized, double-blind, placebo-controlled trial [12] was carried out on 162 children (age 6 15 years) who were randomized in a 2 1 ratio to receive either topiramate (which was titrated over 8 weeks to 2 3 mg/kg per day and maintained for 12 weeks) or placebo.
One large multi-centre RCT [50] examined the efficacy of pregabalin, titrated over 2 weeks to a maximum tolerated dose up to 1200mg/day, in a multicentre, 14 week parallel group, placebo controlled RCT.
The dose was titrated over the next year to 900 mg daily.
LTG doses were titrated over several weeks until the maximum maintenance dose was achieved.
Similar(25)
Apremilast was dose-titrated over the first week of treatment (10 mg on the first day, with increases of 10 mg/day until the target dose was reached).
Of these, the most acidic is PI(4 P with a p K a of around 6.2, which should still titrate over physiological pH, but is possibly fine-tuned for more acidic compartments, consistent with its important function at the Golgi [ 65].
Doses were titrated weekly over a 4-week period up to the maximum doses.
metformin (dose titrated up over 4 weeks starting at 500 mg b.i.d).
Because bromocriptine must be titrated upward over a period of time, patients assigned to tolcapone showed greater improvements early in the course of therapy.
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