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In the case of Type 2A and Type 2B VHL missense mutations, titrated degrees of HIF regulation appear to correlate with the subtype-specific risk of ccRCC [21], [24].
To identify the anti-inflammatory OxPL species, we therefore deliberately varied both the oxidation times and oxidative agents in order to generate a panel of different OxPAPC preparations that exhibited titrated degrees of anti-inflammatory bioactivity.
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Hence, rescuing differentiation in LRP5-KD gluteal cells would require precisely titrating the degree as well as the timing and duration of β-catenin signaling activation prior to and/or during differentiation.
Representative screening 'hits' that included compounds with varying degrees of isoform selectivity were titrated, and the Ki values were determined in the absence of lipids (Table 3).
CPAP-levels were titrated from 4 to 8 cmH20 according to the degree of respiratory distress, assessed by observing the infant's chest retraction, effort of breathing, chest radiograph appearance, and oxygen requirement (stabilize oxygenation until arterial PO2>50 mmHg, while pH>7.20 and arterial PCO2<60 mmHg).
To test the degree of anti-FXa or anti-FIIa potency neutralized by PS, equivalent anti-FXa or anti-FIIa activity doses of different anticoagulant in plasma were titrated with increasing amounts of PS in plasma.
This represents the system to be titrated.
Fe2+ was titrated potentiometrically with K2Cr2O7.
W = gram of sample in aliquot titrated.
Sedation with midazolam was titrated according to clinical response.
Maternal inspired oxygen fraction was titrated from 21%to3%3%.
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