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Patients already on febuxostat or probenecid were maintained on these and the doses were titrated as needed based on sUA.
His treatment regimen included lithium carbonate, 1500 mg/day, carbamazepine, 600 mg/day; haloperidol, 2 mg to 5 mg/day (titrated as needed); and trihexyphenidyl, 5 mg/day.
Patients with fasting plasma glucose (FPG) >270 mg/dl at week 4, >240 mg/dl at week 8, or >200 mg/dl at weeks 12 24 were eligible for open-label rescue medication (500 mg metformin, titrated as needed up to 2,000 mg).
After the 12-hour constant-rate infusion, the infusion rate of dexmedetomidine was titrated as needed between a minimum of 0.1 and a maximum of 2.5 μg/kg/h by titrating the dose stepwise upward or downward to maintain sedation in range of 0 to -3 by using the RASS.
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24 A total of 858 patients on stable metformin doses ≥1500 mg/day were randomised to saxagliptin 5 mg/day or glipizide up-titrated as needed from 5 to 20 mg/day for 52 weeks.
−0.59% for saxagliptin 2.5 mg/metformin* −0.69% for saxagliptin 5 mg/metformin* −0.58% for saxagliptin 10 mg/metformin* +0.13% for placebo/metformin (* P ≤ 0.0001 versus placebo) saxagliptin 5 mg once daily as add on therapy to previously taken metformin glipizide up-titrated as needed from 5 to 20 mg/day as add on therapy to previously taken metformin.
To minimize adverse effects, prophylactic medications are started at the lowest dose and titrated upward as needed.
These agents can be titrated up as needed.
The dose of allopurinol was titrated incrementally as needed to reduce plasma urate to target concentrations.
The starting dose of the single amlodipine/atorvastatin tablet was determined according to each physician's choice, and it was titrated up as needed to achieve the BP and lipid goal (clinic systolic BP < 130 mmHg, diastolic BP < 80 mmHg, and LDL-cholesterol < 100 mg/dL).
The pressure in both our device and in commercial PASG can be varied while they are being used, making it possible for the provider to titrate pressure as needed to control hemorrhage while minimizing discomfort.
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