A central tenant of tissue engineering is that cells should be able to recapitulate full functional tissue capability when placed within an appropriate architecture or scaffold.
CSD under hypoxia or partial ischemia led to an initial increase in NADH levels and a further decrease in CBF during the first phase of the CSD wave, indicating a decrease of tissue capability to compensate for an increase in oxygen demand.
Unfortunately, because the meniscus is not a homogeneous tissue, capability of self-healing in vascular or avascular part is much different.
The accumulation of senescent cells over time most likely reduces the tissue regenerative capability and contributes to the physiological ageing of the tissue.
Compared to electrons soft X-rays have excellent tissue penetrating capability.
Combining such catheter with optical coherence tomography, which can provide subsurface visualization of biological tissue, imaging capability using the active catheter tip is also demonstrated.
At our institute, MRI is the preferred modality due to its excellent soft tissue discrimination capability, large field of view, and ability to provide anatomic, quantitative, and functional information.
Future scaffold-based regeneration strategies should be evidenced to have: (i) superior tissue regeneration capability with excellent long-term clinical outcomes, and (ii) comparable cost with the existing methods.
The in vivo results showed that the tri-layer vascular graft supported cell infiltration, scaffold biodegradation and abundant collagen production after subcutaneous implantation for 10 weeks, revealing the optimal biocompatibility and tissue regenerative capability of the tri-layer graft.
