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Chemical fixation may have altered tissue volume, compared with the live organ, as the standard Karnovsky's fixative is very strongly hyperosmotic (10 mM).
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At 18 months of age, PPARβ−/− mice exhibited lower cortical tissue volume and bone volume compared with PPARβ+/+ mice together with increased endocortical porosity.
The thymus flap is located close to the bronchi and has good vascular flow and sufficient volume compared with other tissues such as muscle flaps such as pleural flap, diaphragmatic flap, and azygos flap.
The outcome of ICU treatment is improved in high-volume compared with low-volume ICUs [ 1].
In each instance, improved repair was reported for the respective treatments, with the lesion being filled to a greater volume of tissue compared with untreated controls; however, the repair tissue generated was mainly fibro-cartilaginous in nature.
Today, with new technologies such as the use of image guided radiotherapy (IGRT) and dynamic intensity modulated radiotherapy (IMRT), it is possible to irradiate the target more accurately [ 9, 10] by reducing the volume of normal tissue irradiated, compared with conventional conformal (3D-CRT) techniques, while allowing to deliver higher doses to the clinical target.
As depicted in Figure 3, at FRC the LPS+inhAPC group presented with a 50% higher volume of well-aerated lung tissue as compared with animals exposed to LPS alone (P = 0.03).
Under the same magnification, Bcl-2 staining intensity was greater in cancerous tissue compared with normal tissues, which might be due to the larger cytoplasmic volume and larger mammary duct compartment in the malignant samples.
This is in contrast to habitual anabolic steroid users who show enlarged volume of central prostate tissue compared with age-matched, eugonadal controls (Jin et al. 1996).
Their final shape yields a 720percentnt volume increase compared with the volume inserted.
In conclusion, the electrospun collagen GAG scaffolds, with high surface-to-volume ratio, may potentially provide a better environment for tissue formation/biosynthesis compared with the traditional scaffolds.
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