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This individualized atlas was used at a later stage to derive regional tissue time activity data from the dynamic PET images.
Less variability in the tissue time activity curves (TACs) was noted after MC (the curves before and after MC for a representative subject are shown in Figure 2).
First, the dosimetry purpose of this work requires calculation of the area under the curve (AUC) of the tissue activity changes with time, i.e. the AUC of the so-called tissue time activity curve (TAC).
Two-ml spheres were placed on axillary and mediastinal LNs and lumbar spine bone marrow as described previously [6], and 5-mm spheres were placed on right and left sides of the lungs to obtain the tissue time activity curves (TACs).
LSGs are also enriched for down-regulated genes in the following: cold stress root tissue (time points: one hour), genotoxic stress shoot tissue (time points: 6 hours) and heat stress root and shoot tissue (time point: 0.25 hours).
Table 1 summarises the tissue time course distribution of [I]-CLINME in rats.
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Data smoothing does not improve the results, and timing errors should be avoided by precise temporal matching of blood and tissue time-activity curves and by replacing manual with automated blood sampling.
As in most dynamic PET experiments, the myocardial infarction (M-I) model is fitted to tissue time-activity curves (TACs) derived from PET scans yielding estimates of the kinetic parameters of interest.
On the basis of estimated ATB, CBF images were recomputed by shifting the time in tissue time-activity curves (TACs).
The ROIs were then placed over the complete series of time frames to derive tissue time-activity curves.
Dynamic PET data of 21 lung cancer patients were retrospectively analyzed, yielding for each patient an 18F-FDG input function (IF) and a tissue time-activity curve.
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