Two ongoing trials (METEOR, NCT01865747 and CABOSUN, NCT01835158) evaluate XL184 in patients with clear cell RCC, both of which require tissue submission from either the primary tumor or a site of metastasis for retrospective correlative biomarker analysis.
From March 2 to April 9, 2002, samples were collected from 505 deer; however, 29 deer were not included in the analysis because of sample autolysis, inappropriate tissue submission, or lack of availability of appropriate tissues (e.g., deer with no intact cranium or those shot in the head).
Our objective was to conduct a prospective study of culture media performance on the routine tissue sample submissions to NVSL.
In addition most NHS Trusts and Universities will have their own Research and Development Departments, which will approve all proposed new research, involving human tissue samples, before submission for ethical approval and scientists should make themselves familiar with their host organisation's local rules and policies.
The spirochete isolates were obtained by culture from clinical submissions of tissue samples transported in isotonic saline or swabs transported in Amies.
A potential limitation to the biobank is that submission of tissue and blood samples is optional and this may impact the exploratory analyses performed in the future.
Submission of tissue samples was not mandatory, and EGFR protein expression was only detected for 57.3 % of the full analysis set population.
Submissions of animals for necropsy or tissue for histology were classified as 'pathology' submissions.
However, if local policies did not permit submission of a tissue block, 10 serial unstained sections could be submitted.
Eighteen tumors and four splenic hematomas included fresh, viable tissue as part of the submission, while the remainder included only fixed or frozen tissue.
