The results from both the Twinkle and PolG patients provide some insight into the tissue specific features of many mitochondrial disorders.
However, because of the tissue-specific feature of eQTL, the findings of this study might not be applicable to other tissues and organs.
Moreover, in agreement with the highly cell- or tissue-specific feature of enhancers, we found that this enhancer is associated with enhancer-specific histone modifications in CRC cell lines, but not in other cell lines, such as the human embryonic stem cell H1 line.
Next, we analysed the tissue-specific features of immune transcriptome responses during CMS.
Table 1 summarizes the tissue-specific features of PXR in cancer development.
Furthermore, using RNA-seq data from four tissues, we analyzed important functional modules and obtained insights into the tissue-specific features of the sweet orange protein interactome.
TLRs are expressed differentially in different tissues and cells (Garrafa et al. 2011), which may in part explain some tissue-specific features of the host response to our microbiome.
75 Although tissue-specific features of fibrogenesis appear to exist, there is increasing appreciation of common pathways of fibrosis that are conserved among tissues, including TGF-β, connective tissue growth factor, interleukins 4 and 13, platelet-derived growth factor and osteopontin.
Most of the spots are tissue specific features which are found only in one or a very few tissue categories such as nervous, immune system or muscle tissues.
The loss of both adipose and muscle tissue is a specific feature of cachexia, making it possible to further distinguish cachexia from sarcopenia, which is characterized by loss of lean but not fat mass.
Moreover, noninvasive T2 mapping reveals the involvement of perimysial connective tissue, that is, a specific feature of the human antisynthetase syndrome [ 28], clearly differentiating HisRS-induced myositis from the CTX model of acute, self-limited muscle necrosis.
