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Overall, our approach can bridge scales from individual cellular events to cell flows and large-scale tissue shape changes.
The anisotropic traceless part v ∼ i j, called shear rate, describes tissue shape changes which conserve the area.
We now want to test whether this tissue description quantitatively accounts for cell and tissue shape changes during wing morphogenesis.
These discrepancies between cell shape changes and tissue shape changes require topological changes in the cell network.
Finally, we compare predictions of this theory to the experimentally measured cell and tissue shape changes and determine key biophysical parameters characterizing tissue material properties.
In addition, the authors develop a fairly simple continuum model for tissue shape changes that can fit all the data in WT, mutants, and ablated embryos.
Similar(49)
The choice of rectangles indeed captures the average shear and area change that determine tissue shape change.
To quantitatively understand the cellular basis of this tissue shape change, we must determine the global patterns of these cellular events throughout the wing blade.
How tissue material properties emerge from the properties and behavior of their many constituent cells, and how these properties quantitatively account for tissue shape change is a major question in developmental biology.
When the compression loads on the disc, the viscoelasticity enables the disc to absorb the energy and dissipate to surrounding tissue via shape changes.
We now present a continuum mechanical theory to understand these force balances and to calculate both tissue and cell shape changes.
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