Exact(12)
This hypothesis is in contrast to the common view of CD36 as a receptor exploited by the parasite for the purpose of tissue sequestration.
In addition to preferential infection of CD4+ NKT lymphocytes by R5-tropic HIV and SIV, Fas-mediated activation-induced apoptosis and tissue sequestration have been implicated as possible causal mechanisms of NKT lymphocyte depletion in pathogenic HIV/SIV infection [43], [45], [48], [49].
These results also rule out differences in tissue sequestration between the two treatment groups.
Mechanisms implicated in CD4 reduction may include decreased production, increased destruction, and tissue sequestration.
But there are problems associated with implantable polymer medical device which include device associated infection [ 4], thrombus formation [ 5], and tissue sequestration of the implant [ 6].
The failure of CD4 T-cell homeostasis in ICL could be attributed to decreased production, increased destruction, tissue sequestration, or any combination of these.
Similar(48)
The intensity of tissue specific sequestration within the eye might be explained by the distribution of endothelial receptors in different vascular beds.
The physical condition response to LPS was accompanied by a decrease in body core temperature, reflecting loss of thermoregulation (Fig. 2B), and reduced circulating lymphocyte and platelet counts (versus vehicle treatment), suggesting tissue lymphocyte sequestration and intravascular coagulopathy, respectively (Supplementary Fig. 2).
The nucleolar protein nucleolin was shown to have specificity for sense G-quadruplex structures, and dispersal of nucleolin staining in the nucleus was observed in C9ALS patient-derived cells and tissue, with sequestration into sense RNA foci visible in the motor cortex.
An important element of TCDD body burden modeling is to better understand the underlying reasons responsible for the decrease in lipid concentrations, which may be caused by dilution in a larger adipose compartment, to tissue-specific sequestration (e.g., to CYP1A2-binding proteins in the liver), and/or to true elimination of TCDD from the body.
For better tissue tolerance, sodium sequestration, K+ retention and resistance to oxidative stress all appeared to be crucial.
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