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Due to the limited amount of bioptic material this sample was not used in the primary tissue screenings.
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Tissue specific screenings were done by transcriptomics and metabolomics of the primary and secondary metabolism [ 18]–[ 20].
Our findings give clear reason to speculate that mtDNA heteroplasmic frequency, distribution, and even its possible role in complex diseases or phenotypes could be severely underestimated, evoking the need for more thorough tissue-based screenings at different age groups to provide more comprehensive understanding about its biological and clinical importance.
We expect that the SSAW-based cell coculture platform demonstrated here will be a valuable tool for studying cell cell interactions, tissue engineering, and drug screenings.
Due to these reasons, one can predict a great boom of RNAi-based genomic screenings using Drosophila tissue culture cells in the upcoming years (22).
At preview screenings, packets of tissues were provided.
Affymetrix screenings were conducted on tissues and cells obtained from WT, p66−/− or p53−/− mice in the sv/129 background.
To address the question whether the organ transduction pattern of clones obtained by in vivo AAV library screenings depends on the target tissue the library was selected for, we also selected AAV libraries for preferential homing into lung tissue.
Wnt signals are implicated in the self-renewal and proliferation of stem cells from a variety of adult tissues [1] [3] but despite numerous large-scale screenings [4] [7], no specific small molecule Wnt agonists have been identified.
Besides, they hold a potential for further development into biomedical applications, from in vitro optogenetics-assisted drug candidate screenings to light-controlled gene therapy and tissue engineering.
Immunohistochemical expression of beta-catenin, cyclin D1, p53 and MSI-screening status had previously been assessed in tissue microarrays with tumours from 280 cases.
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