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Endoscopic techniques are invaluable for tissue samplings as well as the placement of stents in obstructed systems [28].
Although PCR positive tissue samplings were not found at day 30 in the Congo Basin IN challenged animals, in the West African MPXV IN challenged animals in which no symptoms were observed, at 30 days p.i. animals had several positive PCR samples suggestive of systemic infection.
Destructive tissue samplings were carried out 4, 28 and 76 hours after the beginning of the treatment.
Three recent studies have addressed the question of heterogeneity within prostate cancer, identifying multiple foci of differing clonal origin in each case (Cooper et al., 2015; Gundem et al., 2015; Hong et al., 2015) and suggesting that single tissue samplings of a prostate risks missing information about the most important tumour clone.
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These factors can be negatively influenced by tumor heterogeneity and tissue sampling errors.
A disc was considered unsuitable for analysis if it was completely absent, if it contained no tumor tissue (sampling error), or if it contained too few (<10%) tumor cells for analysis (uninformative).
MR-based correction of PET gray matter distribution permits an improved determination of the true radioactivity concentration and reduces partial volume effect mixed tissue sampling errors (Meltzer et al., 1996).
A disc was considered unsuitable for analysis if it was completely absent, it contained no tumour tissue (sampling error), or it contained too few tumour cells (<10%) for analysis (uninformative).
For studying radiotracer uptake in small animal models, the quantitative SPECT imaging has several advantages over purely tissue-sampling-based methods.
We correlated the relationship among tissue-sampling biodistribution, QWBAR, and PET imaging in this study.
For instance, tissue-sampling methods may differ among institutes and even among individuals within the same institution.
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