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During the TEFR09 and under extreme stress, adaptive changes like the increase of the AT diameter could be detected with MRI as well as signs of soft tissue overload with swelling and oedema.
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Complete-arch restorations supported by fewer than 5 dental implants can induce unbalanced load transfer and tissue overloading, leading to excessive bone resorption and possible clinical failure.
There is substantial evidence to support the relationship of mechanical loading to the onset and perpetuation of tendinopathy as a result of alterations to typical loading patterns, inappropriate loading volume or frequency resulting in tissue overloading or underloading.
During functions of speech, facial expressions, swallowing and resting, a denture could cause discomfort simply as a foreign body, even without tissue overloading.
This successfully rescued the phenotype of the knockout mice including reduced birth rates, tissue iron overload, splenomegaly, anemia, leukocytosis, dendritic cell abnormalities, and survival after acute kidney injury induced by rhabdomyolysis or cisplatin nephrotoxicity.
Targeted disruption of the hepcidin-1 gene has been shown to result in severe tissue iron overload [8], whereas mice overexpressing hepcidin-1 develop iron deficiency anemia [6].
However, this process has an inherent tissue volume overload.
Both obesity and T2DM are characterized by tissue fat overload (Fig. 3).
The current epidemic of diabetes is being driven by the obesity epidemic, which represents a state of tissue fat overload.
Uptakes of the latter in hepatocytes, cardiac myocytes, and endocrine gland cells lead to tissue iron overload [ 13].
Increased tissue Fe overload may increase bioactive and protein-bound Fe levels and affect the inflammatory response after an environmental insult.
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