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Branching events often require the coordination of many cells to build a tissue network for material exchange.
The cardiac conduction system (CCS) is a specialized tissue network that initiates and maintains a rhythmic heartbeat.
There are numerous other examples such as Biobank Japan, the Estonian Genome Project, Singapore Tissue Network, Mexico's INMEGEN, and Quebec's CARTaGENE.
In contrast to 2D migration, the 3D tissue network confines and mechanically anchors cells from all sides so that they intercalate alongside and perpendicular to tissue structures [14].
The subcutaneous tissue consists of fat cells that underline the connective tissue network.
Inside the lens, the cortical layer's elastic connective tissue network forms widely spaced lamellae of crystalline fibers.
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To validate this disease-tissue network we examined diseases associated with liver and hypothalamus.
This approach allows us to construct a disease-tissue network that confirms known and predicts unexpected disease-tissue associations.
The bipartite disease-tissue network obtained for is an almost exact subset of the original network obtained for (Supplementary Section V and Fig. S7).
The tissues with the largest number of expressed diseases are BDCA4 dendritic cells (18 diseases), X721 B lymphoblast cells (16 diseases), and CD56 NK cells (12 diseases), appearing as the hubs of the disease-tissue network.
Furthermore, we constructed a multiple-tissue network using QTT from the five tissues for NEFA.
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