Sentence examples for tissue milieu from inspiring English sources

We propose that the age-related increase in cancer results from a synergy between the accumulation of mutations and age-related, pro-oncogenic changes in the tissue milieu.

Thus, ILCs become activated by sensing danger signals from the tissue milieu rather than by antigen presentation with antigen-presenting cells (APCs) (Drake and Kita, 2014; Eberl et al., 2015).

Furthermore, migrating T cells are able to change the tissue milieu.

Recently, there has been intense interest in the potential interactions between adipocytes and macrophages within the adipose tissue milieu.

In the adipose tissue milieu ASP levels increase postprandially, although general circulating levels change little [ 19- 21].

A perhaps less obvious mechanism by which p53 might promote or retard aging is by altering the systemic or local tissue milieu.

This difference in IL-10 function may be attributable to the local tissue micro milieu, as the hypoxic drive and regional soluble and membrane-bound signals in diverse vascular beds may differ, i.e. the retinal vasculature versus the choriocapillaris.

With a few exceptions, most human cytokines are also active on mouse cells [22] [27], so both the combined effects of human and mouse cytokines may have affected the kidney inflammation and tissue homeostasis milieu.

Our present studies suggest that an in cis feed-forward activation mechanism occurs in which the PMN integrates the tissue signalling milieu leading to controlled release of MMP-8 that either directly or indirectly activates LIX in the mouse, and CXCL8 and CXCL5 in man for further PMN migration.

It is a fact that extracellular matrix and tissue biochemical milieu profoundly affect proliferation, motility, cell differentiation and death.

These complex factors and mechanisms suggest that providing the wound with a new viable "tissue" and "milieu" is mandatory to achieve a significant response.