Sentence examples for tissue microenvironment is a from inspiring English sources
For example, the influence of the milieu of tumor development may strongly influence its development, and so an alternative model in which the tissue microenvironment is a critical factor in tumorigenesis has provided the basis for the tissue organization field theory (TOFT) [ 4].
Numerous researchers have concluded that tissue microenvironment is an important determinant of carcinogenesis.
The complex interplay among these molecular signals and the responses they elicit from the diverse cells that comprise tissue microenvironments is an important frontier in our understanding of basic mechanisms of development, adult tissue homeostasis, and cancer.
In addition to different DCs that are present in the spleen and inguinal LN, the tissue microenvironment is thought to have a major impact on the nature of immune responses induced at difference tissue sites.
Recent evidence also suggests that a permissive tissue microenvironment is critical for the growth potential and spread of tumour cells (Kim et al, 2006; Reuter et al, 2009).
An acidic tissue microenvironment is also correlated with energy metabolic dysfunction, mainly because a high rate of glycolysis generates a large amount of lactic acid, which promotes the generation of acidic tissue microenvironment [56].
From the evidence described above, the same principle appears to apply at the primary site: the cancer genotype will only develop into a tumour phenotype if the tissue microenvironment is appropriate.
Such a bicomponent effect of the tissue microenvironment is based on inference from the Sprengel-Liebig's system of limiting factors, initially known as Liebig's Law of the Minimum (summarized in [ 15]).
Where exactly tissue resident macrophages fall in this description is still not clarified but since their reaction to any change in the tissue microenvironment is practically immediate, they will be functionally different depending on the tissue conditions - inflammation being a violent and massive kind of change in the tissue microenvironment.
Secretion of a broad range of bioactive molecules which alter the tissue microenvironment is now believed to be the main mechanism by which MSCs achieve their therapeutic effect.
Mimicking the native tissue microenvironment is critical for effective tissue regeneration.
