Furthermore, the sophisticated experimental technique that we have developed will significantly benefit the field of tissue mechanics by providing knowledge of local mechanical anisotropic properties.
However, these have not been studied together and the mechanism for how mineral structure influences tissue mechanics has not been identified.
Toward this end, we developed a straightforward method for coupling an agent-based model of scar formation to a finite-element model of tissue mechanics, creating a multi-scale model that captures the dynamic interplay between mechanical loading, scar deformation, and scar material properties.
Therefore, our dynamical model omits many connections in the regulatory gene network as well as higher level control mechanism, such as cell-cell interactions, population level quorum sensing and tissue mechanics.
Gundiah studies tissue mechanics and cell mechanobiology.
Setting: A tissue mechanics research laboratory.
The role of endogenously produced hyaluronan on soft tensile tissue mechanics, however, has been largely overlooked.
Covalently bound functional GAGs orchestrate tissue mechanics through time-dependent characteristics.
Yet, suitable and easily accessible model systems for monitoring tissue mechanics at high precision are rare.
Classically, the elastic behaviour of cardiac tissue mechanics is modelled using anisotropic strain energy functions capturing the averaged behaviour of its fibrous micro-structure.
Similarities between the three model types provided confidence in the ability of these models to predict AF tissue mechanics.
