Exact(6)
We took into account elements of biological plausibility, either clinically or experimentally demonstrated, such as tissue infectivity, PrP expression content or successful route of infection.
A positive CI value indicates enhanced tissue infectivity of the parent, whereas a negative CI value indicates enhanced tissue infectivity of the mutant; CI = 0 is the no-effect value.
A paired Student's t test was used to test the null hypothesis (CI = 0) that there was no difference in tissue infectivity between the parent and the Δpvl mutant.
In line with recent published studies, the 2010 updated World Health Organization tables on 'Tissue infectivity distribution in transmissible spongiform encephalopathy' moved urine from the category of 'Tissues with no detectable infectivity' to the category of 'Lower-infectivity tissue' (the latter category includes blood) [22].
Like vCJD, classical scrapie is associated with widespread tissue infectivity, mainly in the central nervous system (CNS), peripheral nervous system (PNS), and lymphoreticular system (LRS) [ 4].
The recently published WHO classification of tissue infectivity in TSEs [ 14], though aimed at public health issues radically different from those addressed in our study, may nonetheless serve as a conceptual framework for a tissue classification in terms of risk level of prion acquisition.
Similar(2)
The main source of infection is believed to be the placenta as this tissue contains infectivity [ 4] and PrPd [ 5].
Virus production was measured by titration in Neuro-2a cell line and expressed as tissue culture infectivity dose50/ml (TCIdose50/ml
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