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Therefore, controlling tissue fusion can be achieved through adjusting the ATST of bioprinted spheroids via our fabrication method.
During the tissue fusion process, the individual tissue spheroids also change their shape from ball-like to a conus-like form.
Closely placed tissue spheroids undergo tissue fusion — a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly.
While spheroids can be assembled using passive contacts for the fusion of complex tissues, physical forces can be used to promote active contacts to improve tissue homogeneity and accelerate tissue fusion.
The phenotype was the result of a combination of hard and soft tissue fusion.
Tissue fusion between allocompatible siblings developed within several days of settlement.
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Harnessing the ability of corals to 'self-anchor' to substrates and of tissue fusions between isogeneic fragments, we develop here a novel ecological engineering approach based on the 2D Coral Preparative (2D-CP) tool.
All of the mutant mice examined exhibited soft tissue fusions and fused nails of digits 2 and 3. Skeletal staining also revealed the fusion of the distal phalanges of digits 2 and 3 (Figure 6I).
Analysis of allorecognition responses revealed an array of effector mechanisms: real tissue fusions, transitory fusions and six other histoincompatible reactions (borderline formation, sutures, overgrowth, bleaching, rejection, and partner death), disclosing unalike onsets of ontogeny and complex modes of appearance within each aggregate.
We have previously reported that BMDC fusion occurs with a stem or progenitor population in the intestine [8], whereas in other tissues fusion takes place with differentiated cells [1], [7], [12], [22].
Surgical therapies include decompression with partial discectomy (removal of the diseased IVD tissue), spinal fusion of the affected segment, or partial or total artificial IVD replacement [ 2, 3].
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