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In this study, TAV and SAV leaflet fatigue due to cyclic loading was investigated through finite element analysis by implementing a computational soft tissue fatigue damage model to describe the behavior of the pericardial leaflets.
It has been suggested that repetitive and force demanding tasks lead to tissue fatigue failure [ 7, 8], initially with inflammatory processes, followed by fibrotic processes.
The incomplete masking of the epitope could be exacerbated in vivo by the tissue fatigue, to which the valve is submitted in the patient's arterial circulation.
However, with GAG depletion, the amount of fascicle stress relaxation increased and the failure stress subsequently decreased, implicating a protective role of GAGs towards limiting viscoelastic behaviour and thus preventing tissue fatigue.
This may be viewed as a negative effect, in light of current hypotheses related to the protective effects of motor variability against tissue fatigue and over-use injury, and suggests that LB are a poor long term solution for patients.
According to a recent hypothesis [ 37, 38], such a reduced variability may be detrimental for musculoskeletal health, particularly when repetitive work activities are performed, as it will lead to repetitive loading of the same anatomical structures, and potentially to mechanical tissue fatigue.
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However, RT is associated with acute or chronic side effects such as injury to normal tissues, fatigue, nausea/vomiting, diarrhea, and intestinal bleeding.
In particular, progressive appetite loss, weight (lean tissue) loss, fatigue and pain are extremely debilitating not only impacting on quality of life but also the response to treatment and survival.
Furthermore, previous studies have indicated that elevated levels of reactive oxygen species (ROS) may predispose muscle tissue to fatigue [ 14] and that ROS are signaling molecules involved in muscle adaptation; furthermore, redox-sensitive kinases, phosphatases, and nuclear factor-κB have been implicated in muscle loss [ 15].
Theoretically, the high metabolic rate may accelerate [ 73, 74] the process of recovery of muscle tissues from fatigue in CFS [ 24, 25, 75, 76] and some studies indeed show accelerated muscle recovery following immersion in cold water [ 77, 78].
"What we don't want is to find ourselves with another soft tissue injury and fatigue brings soft tissue injuries".
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