Taken together, incorporation of tissue driven molecular analysis of the sub-type specific drivers and mutational spectrum in HNC and EMT offers great translational potential.
The electric field induced in the neuronal tissue drives ionic currents that charge the capacitances of neuronal membranes and, thereby trigger the firing of neurons.
Tumor tissue driven responses of primary T cells were paralleled by NFAT activation measured in CAR-transduced Jurkat T cells, which was shown to be triggered in a CAR and antigen-specific manner.
The role for IFN-γ is not as well established in the pathogenesis of myocardial disease; however, transgenic mice that constitutively express IFN-γ in liver tissue driven by the liver specific promoter of human serum amyloid P component (SAP) gene were recently shown to develop chronic active myocarditis and cardiomyopathy [48].
Spread of inflammation to the adjacent connective tissue drives the destruction of connective tissue and alveolar bone, that is, the cardinal sign of periodontal disease [ 9].
Adipose tissue produces adipokines that inform the brain about whole-body long-term energy-storage status, and the tissue drives the brain's control of energy balance and the long-term regulation of body weight.
Therefore, the oligoclonality of the antibody repertoire, deriving from a tumor microenvironment, is a natural immune response occurring within tumor tissue driven by tumor antigens, and not an artifact introduced by PCR amplification.
The further slow expansion of this primary pattern reflects tissue movement driven by continuing proliferation of the posterior disc, and convergent extension of the forming segments as the whole egg epithelium condenses anteriorly and cells move into the germ band.
We conclude that highly specific genes that have diminished expression in the cancerous tissues drive the drop in specialization, similar to that seen in dataset A. The data from the "Human Transcriptome Map" (dataset C) consist of a collection of SAGE gene tags that belong to heterogeneous normal and tumor tissues that are grouped by chromosome.
In contrast, no GUS staining was observed in all corresponding tissues of the negative control, non-transgenic Nipponbare (Figure 4B, D, F, and H). Figure 4 GUS histochemical staining results in different tissues driven by pSH4.
