Sentence examples for tissue distribution volume from inspiring English sources

The gradient of the plot, which represents tissue FDG clearance (Ki), was divided by the intercept, which represents tissue distribution volume of FDG (V 0)—see Eq. 3).

Time-activity curves (TACs) were generated from the dynamic PET datasets and Logan graphical analysis82 for reversibly accumulating radiotracers was used to calculate the apparent tissue distribution volumes (DV) of [18F]TFAHA-derived radioactivity in 9L tumors and different structures of the brain.

Whilst there has been much interest in measuring FDG clearance in several tissues for many years, there has been less interest in the physiological significance of tissue FDG distribution volume.

In addition, in a recent study proposing a physiologically-based pharmacokinetic model for improving the prediction of tissue distribution and volume distribution of highly lipophilic compounds [19], the simulation of the partition coefficient for adipose tissue was considered more sensitive to lipophilicity, by comparison with a non-adipose tissue.

(1892) Therefore, the product of the PTP value and the volume of the tissue can be viewed as the distribution volume of the tissue.

In conclusion, tissue FDG6P concentration depends on FDG clearance per unit total volume but the FDG6P/FDG concentration ratio depends on tissue clearance per unit distribution volume.

Table 2 Kinetic modeling results in humans using a two-tissue compartment model   Compartmental distribution volume Region V T (mL · cm−3) Frontal cortex 0.092 ± 0.016 (14.2%) Temporal cortex 0.102 ± 0.010 (4.4%) Parietal cortex 0.087 ± 0.011 (4.9%) Caudate 0.086 ± 0.024 (22.6%) Cerebellum 0.090 ± 0.010 (2.8%) Representative brain regions from the three human subjects.

To investigate difference in the amount of nonspecific binding between the two reference tissues, we measured distribution volumes in these tissues.

An important tissue transport quantity is the distribution volume: v_{d} equiv frac{k_{1}}{k_{2}+k_{3}}.

However, PVP showed the minimum volume of tissue distribution.

V represents the initial distribution volume in the tissue of interest at time 0, calculated from the Patlak plot y-intercept.