Further, Mo et al. [ 13] developed a MC code to simulate the sampling volume of a ball-lens fiber probe depending on diameter and refractive index of the ball lens and probe-tissue distance.
As in our previous studies, we present the red-to-blue (R/B) intensity ratio rather than the red intensity alone, because taking the ratio of the emitted red signal to a portion of the blue excitation light helps eliminate variations due to day-to-day fluctuations of the excitation source strength and geometrical factors such as probe-to-tissue distance (Zheng et al, 2002).
The tip of the electrode was placed close to the root tissues (distance < 1 mm).
Among the 46 peritumoral tissues (distance from cancer ≥ 3 mm), 10 tissues were normal, 10 tissues were mild dysplastic, 12 tissues were moderate dysplastic, and 14 tissues were severe dysplastic.
These more idealized studies make use of minimal electrode-tissue distances and small or infinitesimal electrode sizes.
Every patient sample was divided into three parts, namely tumor tissues, adjacent tissues (the distance from tumors was greater than 2 cm but less than 5 cm) and normal tissues.
Despite promising results, there are still some limitations to the method used concerning a lack of orientation before ICG application, as well as results depending on light and tissue geometry, distance and automatic camera settings such as integration time and gains.
Placing an osteoconductive material, such as a bone graft, in the chamber can increase the tissue ingrowth distance [ 6].
Similarly, researchers found that gene expression pattern is more significantly related to physiological condition rather than tissue spatial distance [ 69].
Thus, the tissue ingrowth distance from the holes towards the other end of the chamber can be measured as an estimate for tissue regeneration.
