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We found cellular mtDNA depletion only in individuals with clear tissue depletion (Table 2).
Patients with tissue depletion of mtDNA all had at least one allele with either a missense mutation in a catalytic domain or a nonsense mutation.
Weight loss, lean tissue depletion, lipoatrophy, anorexia, nutrient malabsorption, diarrhea-induced nutrient losses, and a hypermetabolic state increase risk of death.
We found that the cellular phenotype correlated better with the location of the mutation and the severity of the tissue depletion than with specific clinical features.
The postmortem examination showed marked subcutaneous and visceral adipose tissue depletion, as well as moderate skeletal muscle loss, especially in the axial skeleton.
The Yoshida AH-130 rat ascites hepatoma is a model system for studying the mechanisms involved in the processes that lead to tissue depletion, since it induces in the host a rapid and progressive muscle wasting, primarily due to TPH.
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"What this therapy has done is show that there is a clear-cut possibility of ameliorating the lean-tissue depletion," Schambelan says.
In engineered cardiac tissues, depletion of CXCR4 or CXCR7 had opposing effects on developed force and chronotropic response to β-agonists.
Additionally, because of its antioxidant activity in normal tissues, depletion of glutathione (GSH), a by-product of Gln metabolism, may increase the extent of tissue damage caused by C-CRT [ 3, 6, 7].
In normal tissue injury, depletion of vimentin delays wound healing by mesenchymal fibroblasts trans-differentiating into epithelia [23].
Patients with demonstrable tissue mtDNA depletion always had at least one catalytic domain or nonsense mutation.
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