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In adipose tissue, conversion of androgens to estrogens by aromatase occurs [ 22].
GH increases the tissue conversion of active cortisol to inactive cortisone.
Attempts to correlate adrenal precursor steroids with breast cancer incidence have been relatively successful, or at least consistent, perhaps reflecting the importance of local tissue conversion.
Tissue resistance to cortisol may occur as a result of abnormalities in the glucocorticoid receptor or increased tissue conversion of cortisol to cortisone.
For tissue RAAS-activity other mechanisms may be relevant as high sodium increases tissue conversion of angiotensin (ang) I [ 24] and annihilates the effects of ACEi on tissue ang I conversion [ 25].
Critically ill patients with prolonged stays in an intensive care unit may develop vitamin D deficiency for a number of reasons, including lack of exposure to sunlight, malnutrition, decreased renal 1α hydroxylation and increased tissue conversion of 25(OH)D3 to 1α,25(OH)2duringing acute stress and the inflammatory response [ 8, 9].
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Injuries due to electricity occur by three mechanisms: Direct effect of current on body tissues; conversion of electrical energy to thermal injury resulting in burns; and blunt mechanical injury from lightning strike, muscle contraction or complication of a fall afterwards.
In obesity, the excess of adipose tissue increases conversion of androstenedione into estrone, an estrogen.
Sucrose is also translocated from the leaf to sink tissue for conversion into long-term carbohydrate storage compounds such as starch or fructans.
In postmenopausal women, estrogens are mainly synthesized in the fat tissue, through conversion of androgens, whereas in premenopausal women, estrogens are mainly synthesized in the ovary [ 38].
Thus, XDH can be an important redox-regulated source of O2– generation in ischemic tissue, and conversion to XO is not required to activate radical formation and subsequent tissue injury.
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