The mammalian NAD+-dependent protein deacetylase SIRT1 and the key NAD+ biosynthetic enzyme NAMPT mediate these inter-tissue communications.
In this review, the function of each organ or tissue and their inter-tissue communications will be discussed in terms of understanding mammalian aging and longevity control.
Cooperative functions of SIRT1 and NAMPT, both iNAMPT and eNAMPT, play a crucial role in regulating the system dynamics of this inter-tissue communications.
The NAD World 2.0 is a reformulated version of the original concept of the NAD World, emphasizing the importance of the inter-tissue communications between the hypothalamus as the control center of aging/controller, skeletal muscle as an effector/actuator, and adipose tissue as a modulator/possible sensor in the systemic regulation of aging and longevity in mammals.
We assumed that inter-tissue communications would be reflected in the inter-tissue gene correlations.
Wang K, Sun W, Richie CT, Harvey BK, Betzig E, Ji N, "Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue", Nature Communications (2015) 6, 7276.
Although we focus here on brain gut adipose-tissue communication pathways, it is important to acknowledge that other important CNS-peripheral communications (such as those involving muscle and brain gut adipose-tissueso communication energy homeostasis.
While studies of cultured cells have led to new insights into biological control, greater understanding of human pathophysiology requires the development of experimental systems that permit analysis of intercellular communications and tissue-tissue interactions in a more relevant organ context.
In addition to the differences between acute and chronic inflammation, a difference between local and systemic wound responses, in terms of inter-tissue and organ communications, also exists [ 58].
…vital tissue in the accessory communications was not removed during canal shaping and cleaning and although lateral canals appeared radiographically filled they were actually not obturated, and the remaining tissue in the ramification was inflamed and enmeshed with the filling material.
Our network analysis demonstrated that five genes of this set were functionally related to pathways which enable tissue formation and intercellular communications: "adherens junction," "focal adhesion," and "tight junction".
