Although we focus here on brain gut adipose-tissue communication pathways, it is important to acknowledge that other important CNS-peripheral communications (such as those involving muscle and brain gut adipose-tissueso communication energy homeostasis.
In recent literature, a soft-tissue communication between the rectus capitis posterior major (RCPma) muscle and the cervical dura mater has been identified.
Alternatively, this inter-tissue communication might be produced by the interaction of two cell populations with different adherent properties such that cells failed to adhere with different tissues propagate a cue for the polarity.
Cell-to-cell and/or tissue-to-tissue communication is crucial for tissue organization.
Together these findings indicate that muscle-derived Myoglianin systemically regulates nucleolar function across aging tissues in Drosophila and that this inter-tissue communication extends lifespan [ 4].
Ghrelin is thought as a novel paracrine/autocrine factor expressed in endometrium and placenta that is involved in crosstalk between endometrium and embryo during embryo implantation [ 72], which may indicate that such intra-tissue communication is critical for implantation success.
Miyaki and Asahara (2012) mentioned that extracellular miRNAs may play a role similar to cytokines, and could be considered to be paracrine regulatory molecules for cell-to-cell or tissue-to-tissue communication.
These results suggest that miRNA may not only function as regulatory molecules within cells such as SFB and chondrocytes, but also as components of exosomes contributing to OA pathogenesis by mediating cell-cell and tissue-tissue communication in osteoarthritic joints.
All actors would be part of the same connective tissue or communication network.
21 During this time, the pancreas undergoes a developmental rearrangement that results in a wave of programmed cell death involving both exocrine and endocrine pancreatic tissue (personal communication).
It may be of interest then to go to the genomic level, and to identify quantitative trait nucleotides, and investigate the biological mechanisms (at the levels of transcription, translation, protein function, cell phenotypes, tissue organisation/cell communication and organismal physiology) that underpin the variation observed.
