In non-tumor bladder tissue, lovastatin treatment did not significantly increase tissue accumulation of 89Zr-trastuzumab.
After the tissue accumulation experiments, 5 μm and 20 μm pristine PS-MPs were used for toxicological experiments.
How to cite this article: Deng, Y. et al. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure.
Hence, data on tissue accumulation of MPs in mammalian models would be indispensable for risk assessment of MPs in human health.
Observed effects in fish include intersex changes, impaired reproductive potential, and tissue accumulation of active substances.
Mucopolysaccharidosis type III is a group of four autosomal recessive enzyme deficiencies leading to tissue accumulation of heparan sulfate.
These complications may be caused by glycosylation of ocular tissue or nervous tissue, accumulation of osmotically active glucose metabolites in these tissues, or disease of the small vessels in these tissues.
While most researches on the toxic effects of MPs have focused on aquatic organisms, studies documenting the potential health risk and tissue accumulation of MPs in mammals are lacking.
Tissue accumulation of MPs may induce various adverse effects, such as physical injury22, reduction of feeding activity23, inhibition of growth and development24, energy deficiency3, immune responses25, oxidative stress26, neurotoxic responses27, metabolic disorder28, and genotoxicity13.
Both MPs sizes tested here displayed tissue accumulation over time (Fig. 1) and were clearly visible as distinct fluorescent points in the liver, kidney and gut of exposed mice.
S-methyl ET followed a similar tissue accumulation trend with that of ET (Fig. 8), with tissue levels of S-methyl ET increasing after 7 and 28 days of ET administration.
