Either the single base substitution of the DRE core sequence or point mutation of the key amino acid in TINY DNA-binding domain greatly reduced the binding strength.
I was relieved to find Judith Leyster's tiny but spell-binding Proposition (1631) and Clara Peeters' genre-defining Still Life with Cheeses, Almonds and Pretzels (1621) in the Hague's Gemeentemuseum.
Consequently, any comparative analysis of nonrepetitive unknowns with reference materials is very unlikely to provide satisfactory molecular resolution, because rather tiny variations in chemical binding may strongly and often unpredictably affect the properties commonly used for detection, such as retention times and spectral signatures.
In parallel, tiny clusters of nucleic acid binding and metal ion binding activities were observed.
Since only a tiny fraction of the protein/ligand binding predictions were assessed experimentally 20-500 of the top ranked predictions from FINDSITEcomb), these success rates are even more significant than the raw numbers would suggest.
Although, and as discussed above (Figure 7A), only a tiny subset of Ubx monomer binding sites are actually bound by Ubx, motifs matching Ubx PWMs were identified multiple times in these data sets.
The expected concentration, cE, that a Ca2+ ion exerts upon a nearby receptor, Δ S nm away after τ ms, was used to calculate the probability of not binding during a tiny time interval Δ τ ≫ Δ t.
More interesting, it was found that 19th amino acid mutation of TINY resulted in the decrease of the binding force but the binding probability was the same as the wild type TINY.
The artist's spell-binding compositions weave together tiny pearlescent nodes and shocks of spiky bursts.
Centuries later, the manuscript is placed in the hands of a rare-book expert, who discovers a series of mysteries in the tiny artifacts contained in the book's binding. .
