Rif1 loss affects both number and replication-timing specificity of the interactions between replication-timing domains.
Receptors activated solely by synthetic ligands (RASSLs) offer control over the location, timing, and specificity of a G protein signal in vivo.
To gain control over the timing and specificity of a G-protein signal, receptors activated solely by synthetic ligands (RASSLs) have been developed.
To increase our understanding of these processes, we sought to gain control of the timing and specificity of Gs signaling in vivo.
Understanding the factors that control the timing and specificity of bacterial colonization will provide insight into communication among the multiple partners in the coral holobiont and identify significant determinants in host vulnerability to bacterial disease and changing marine environments.
Because RASSLs lack endogenous agonists, they allow greater control of the timing and specificity of activation than is possible with endogenous receptors.
Dynamics of transcription factor activation determine the timing and specificity of gene expression and phenotype responses (Werner et al., 2005; Kobayashi et al., 2009; Purvis et al., 2012).
For both approaches, identification of suitable candidates for therapy, appropriate dosage and timing and specificity of intervention are critical for successful intervention.
To examine the timing and specificity of SRP recruitment, a variety of stalled ribosome-nascent chain complexes (RNCs) were prepared by in vitro translation of truncated mRNAs in rabbit reticulocyte lysate, affinity purified via the nascent chain, and analyzed biochemically.
