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As shown in Table 2, false discovery rate (FDR) is well controlled for all methods when mutation rate is assumed constant across replication timing region and expression level.
The locus lies within a short (c. 50 kb) early constant timing region and is surrounded by two stretches replicated just before it (Fig 1C and Supplementary Fig S1B) (Sarkies et al., 2010).
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In a recent quantitative meta-analysis of the neuroimaging literature on temporal processing, Wiener, Turkeltaub and Coslett [47] demonstrated that many so-called "timing" regions showed differential probabilities of activation depending on the type of timing task employed.
He adds: "Although there are timing differences, the regions go through the same cycles.
Intriguingly, in both yeast species, DDK is also involved in advancing replication timing at centromeric regions, which is the focus of the next section.
This method has the advantage over fMRI in that categorization and recognition can be disambiguated by differences in both timing and region.
The replication timing program of telomeric regions on human chromosomes might be regulated by specific mechanisms that differ from those for other chromosomal regions.
Although reviews of the literature on timing have generally supported the basal ganglia timing hypothesis (e.g. [1]), there exists a lack of consistency concerning the necessity of other neural regions for timing.
Such movements generally occur between late June and August with timing variations attending species and region [ 16].
We also evaluated the timing of regions for five ovarian tumors with WGS available through the TCGA project (Cancer Genome Atlas Research Network, 2011).
To determine if the changes in late replication pattern are a reflection of changes in the heterochromatin organization, we examined the replication timing of regions that showed a reduction in H3K9me2 and H3K9me3 upon ORCA KD.
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