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LIN-41 is best known for its role in the developmental timing pathway in somatic cells where it is a target of the let-7 microRNA (Reinhart et al. 2000; Slack et al. 2000; Vella et al. 2004; Bagga et al. 2005; Del Rio-Albrethtsen et al. 2006; Harris and Horvitz 2011; Vladia et al. 2012; Zou et al. 2013).
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All xenoestrogens shared activation via all pathways, although compounds differed in their timing of pathway engagement.
Amid all that, there's of course the opportunity to simply use Google Maps to find the right timing and pathway to get to your destination.
Unfortunately, evidence for the relative contribution of different pools of Cd (i.e. roots, stems, and leaves) to Cd accumulation in the grain, and for the timing and pathway of Cd transport to the grain is contradictory.
Because many practices reduce water retention times and alter the timing and pathways of water flow, local decisions regarding land use can potentially exert a major influence on watershed N export.
Microbes and PAMPs could activate both pathways at different timing; a rapid pathway would act through a RBOH mediated ROS production and use the "ROS pathway", while a later "SA pathway" requires increased SA biosynthesis and NPR1.
For convenience, we termed this type of synaptic plasticity as the timing of afferent pathways dependent plasticity (TADP), because it shares some but not all properties with STDP.
In animals, this includes regulation of developmental timing and signaling pathways, apoptosis, metabolism, myogenesis and cardiogenesis, brain development [ 3], and human pathologies [ 6- 8].
A consistent international observation is the lack of confidence of GPs in diagnosing subtypes of shoulder pain 22 23 and this may have a critical bearing on the appropriateness and timing of care pathways for patients with shoulder conditions.
"We hit [the rats] with a hammer so we could see what the end point was," Skinner says, adding that more research is needed to determine the implications for real-world human doses, exposure pathways, timing, mixtures, and other factors.
A variety of additional factors may contribute to such deviations from predictions, including oceanographic variability in dispersal pathways, timing and location of hatching and larval release, larval behaviour and mortality, and local adaptation (Faurby and Barber 2012).
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