This description is not realistic: (i) it is not verified by experiments and (ii) timing and orientation constraints make it complex which seems to contradict the required adaptability.
We analyzed the divisions of the gonadal precursor cells at the L1 stage in cye-1 mutants and found that they divided twice with the same timing and orientation as in wild type (n>10, data not shown).
We could reveal detailed similarities with single cell resolution pertaining to different levels of potential homologies, such as cleavage tree pattern, fate restriction, morphogenetic movements, timing, or orientation of planes of cell divisions.
Although the mechanism for variation in microsatellite mutations is unknown, neither replication timing nor orientation can account for it, suggesting that other aspects of genome structure can influence the mutation rate.
Genetic mechanisms underpinning various aspects of migratory behavior have been discovered in animals that traverse great distances and display precise homing ability (e.g., timing, sun compass orientation, and propensity to migrate; Zhu et al. 2009; Hecht et al. 2013; O'Malley et al. 2013).
Likewise, a successful return to the natal river and arrival to the spawning grounds will be contingent on homing orientation, time spent at sea, timing of return and timing of river entry.
The literature regarding entry timing suggests that pioneering orientation (PO) is a key determinant factor of new product performance (NPP) due to 'first mover advantages'.
Important variables considered in the simulations were facility allocation, cow space needed in each farm area, robot utilization, number of cows, milk yield, milk flow rate, feeding method and timing, robot location and orientation, and farm physical layout.
Thermo-mechanical modeling allowed reproducing fairly well the location, orientation and timing of the first fracture; indeed, fractures should be avoided to ensure cavern integrity, and therefore knowledge about the critical zones where fractures could appear is sufficient at the design stage.
The circadian clock plays a vital role in monarch migration by providing the timing component of time-compensated sun compass orientation [7] [10], which contributes to navigation to the overwintering grounds.
