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This data must obviously be interpreted with caution, given the unplanned timing of the analysis.
This upregulation contrasts with the finding of a reduced expression of CD11b in monocytes after LPS inhalation in asthmatic subjects [ 27] but differences in timing of the analysis and dose of inhaled LPS may account for the difference.
The timing of the analysis differs among the studies (i.e., evaluation of maximum signal intensity [ 19], evaluation of the late phase of contrast enhancement [ 23]) as well as the unit of measurements (i.e., dB-enhanced [ 20], percentage ratio between area of plaque captation and silent areas [ 19]).
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The timing of this analysis at 10 hours post synchronization coincides with the peak of var gene expression determined by a time-curve assay (data not shown).
This timing error of the analysis window results in a phase rotation of the received MCLT coefficients, and this may lead to decoding errors.
Of note, the timing of the metabolomic analysis (blue arrows) was deliberately chosen before the onset of cell death, to avoid any confusion arising from metabolic changes associated with apoptosis.
This latter study deduced younger ages (4 8 Ma) but did not actually carry out a timing of the divergence analysis, rather they only calculated pairwise genetic distances with Kimura 2-parameter without an adequate model testing.
Another member of the monocarboxylate transporter family, SLC16A7, was shown to be down regulated following renal ischemia-reperfusion in mouse [ 29], however as stated above this may be attributed to differences in the degree of injury and timing of the genomic analysis post injury.
Li et al. [ 55] suggested that a mathematical determination of optimal timing through the analysis of the REV-ERBα and BMAL1 regulatory transcription loop could improve tolerability to chemotherapy.
By combining our analysis of the relative timing of the rearrangement events with the analysis of sequence features associated with the boundaries of these events, we have formulated a cohesive model for the structural evolution of the N. tetrasperma mating-type chromosome.
The timing of initial analysis was criticised for being after only 2 years of follow-up; however, initial analyses were planned when all patients had at least 3 years of follow-up, and at the time of this analysis the median follow-up of primary analysis patients was 59 months.
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