The model simulations suggested that moderate delays in geographic spread may be possible with stringent restrictions and a low reproduction number, but results will be sensitive to the reproduction number and timing of restrictions.
These results appear to be dependent on the experimental conditions, duration or timing of food restriction, and fish species.
Weibo blamed the situation on a systems upgrade, but the timing of the restriction made it seem like a method to prevent content that would be deemed unsuitable by authorities.
Our study is the first to show that maternal UN significantly reduced primordial, secondary and antral follicle number in adult offspring in a manner that was dependent upon the timing of nutrient restriction.
These data demonstrate that maternal undernutrition (UN), imposed at defined critical windows of development and resulted in significant reductions in primordial, secondary and antral follicle number in a manner that was dependent on the timing of nutrient restriction (see Table 4, summary).
This is approximately the same stage at which dazl expression commences (supplementary material Fig. S5), and it is consistent with our data on the timing of germline restriction.
Better understanding of the molecular determinants of cell fate decisions and the precise timing of lineage restriction during early embryo development is essential for effective use of stem cells.
These data demonstrate that mix is sufficient to interfere with PGC development, and we reasoned that its conditional activation might provide a system to investigate the timing of germline restriction.
The article also misstated the timing of those restrictions.
Full details of the study/clinic visits, the timing of assessments, restrictions related to food, drink and exercise intake, and assessment of treatment compliance are provided in the Online Supporting Information.
Our results demonstrate in extraordinary detail the multitude of developmental levels amenable to evolutionary innovation, including subtle changes in the timing of fate restrictions as well as dramatic alterations in complex morphogenetic movements.
