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The aim of this study was to analyse the extent of generic and branded substitution for a number of popular drug classes in the northern Netherlands and subsequently to quantify the effect that several patient and pharmacist characteristics, as well as the timing of prescriptions had on the likelihood of generic or branded substitution by the pharmacist.
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No difference in the severity of the cases (assessed by SAPS II and SOFA scores) was observed according to the timing of prescription, the type of prescriber, or the time to initiation of AT.
We aimed to estimate correspondence between general practitioner (GP -reported treatment and timinGP -reportedptreatmentensandon.
Compliance was followed by timing of prescription renewal with minimal differences identified between treatment groups.
The retrospective character of this study makes it impossible to date the exact duration and timing of prescription.
Objectives To investigate whether the use and timing of prescription of β blockers in patients with chronic obstructive pulmonary disease (COPD) having a first myocardial infarction was associated with survival and to identify factors related to their use.
To investigate the effect of timing of prescription of β blockers, we divided people into those with no evidence of β blocker prescription over the study period, those who had been prescribed β blockers before their myocardial infarction, and those prescribed β blockers for the first time in the immediate aftermath of their myocardial infarction (during their hospital admission).
Objective To provide absolute and relative risk estimates of neonatal abstinence syndrome (NAS) based on duration and timing of prescription opioid use during pregnancy in the presence or absence of additional NAS risk factors of history of opioid misuse or dependence, misuse of other substances, non-opioid psychotropic drug use, and smoking.
In particular, we analyzed the behaviour of the pharmacist with regard to generic and branded substitution by using information related to patients' and pharmacists' characteristics and the specific timing of the prescriptions and deliveries.
In addition, since β-blockers, diuretics, and systemic steroids are known to be associated with an increased diabetes risk, we also assessed the number and the timing of previous prescriptions for these drugs and compared such drug use before the index date between diabetes case and control subjects.
Overall our findings suggest that even though generic delivery is strongly connected to generic prescribing, the event of generic substitution, when it occurs, is mainly affected by the type of the pharmacy ownership, the timing of the prescription, the type of the drug and the patient's age and experience with the drug.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com