Given the pivotal role of surrogate outcomes in drug development, and the observed variability in surrogate acceptability both within and between international agencies, more clarity is needed on the nature and timing of evidence needed to validate surrogate outcomes.
To deliver NHS Health Checks effectively, the location and timing of events needs to be carefully considered and staff need to be provided with the appropriate training to ensure patients are supported and enabled to make lifestyle changes.
Research should determine the optimal types, doses and timing of interventions needed for different groups of cancer survivors, depending on survivors' individual biology, sociodemographic characteristics, outcome needs and psychosocial circumstances, recognising that one size will not fit all.
An important advantage of hierarchical linear modeling, however, is that the number and timing of observations need not be the same across all subjects [ 17, 47].
Each disaster uniquely shapes the types and timing of information needed both to manage the disaster and to measure the impact on available resources, the environment and community systems.
The timing of family needs may cause postdocs to miss important events on the academic calendar.
However, it is clear that political commitment is crucial, and the timing of implementation needs to be matched closely to the electoral cycle.
Melatonin treats Circadian Rhythm Disorders (where you sleep the right amount of minutes but your body clock is at the wrong time), Shift Work Sleep Disorders and early morning awakenings -- all things that deal with the timing of your need to sleep.
The optimal timing of imaging needs to be ascertained in future studies.
Similarly, the timing of therapy needs to be closely monitored.
