Sentence examples for timing of mutations from inspiring English sources

In our work, the relative timing of mutations is inferred by longitudinal data with multiple time points.

"The timing of mutations must be earlier than the separation of populations," says Stanford geneticist Luca CavaLucaSforza.

Remarkably, the pivotal role of the timing of mutations in determining the severity of phenotype in TSC mouse models is supported by observations in mTOR-hyperactivating embryonic and postnatal NSCs.

Major comments: 1) Relative timing of mutations: It is not entirely clear in the Materials and methods or main text exactly how the temporal order of mutations is inferred.

We show how the magnitude, type, and timing of mutation can also affect fitness, invasion and diversification.

The forces that dictate this steady state obscure frequency fluctuations due to timing of mutation events.

This information can be used to infer the relative timing of mutation acquisition during tumor development as well as to assess tumor heterogeneity.

Mutational mapping also records the timings of mutations across the tree, which we have used in calculating evolutionary rates, whereas existing maximum likelihood methods do not.

B) To address the major comment #1, we introduce a phylogenetic tree method to infer timing order of mutations.

The projected timing of key mutations during cancer growth suggests that mutations in cancer-associated genes may initiate carcinogenesis and lead to genetically-distinct cell lineages that influence resistance to treatment.

To investigate the timing of p53 mutations in gastric cancer, we employed the restriction site mutation (RSM) assay (Myers and Parry, 1994).