The exact timing of mortality was not known; during a cooling trial, larvae entered chill coma and ceased moving, and we were thus unable to determine mortality due to beam exposure from our x-ray imaging alone.
In our analysis there was also no subgroup heterogeneity evident for timing of mortality observation (table 3 and online supplement).
Timing of mortality was based on presentation to the SNCU, which was considered 'time 0'and equivalent to admission in this context.
Maximum recorded life span represents the greatest recorded age of death for a species and reflects the timing of mortalities owing to intrinsic, biological causes (often in captive animals).
Most earlier cross-sectional studies during the 1990's, which have addressed the relations between timing of menopause, mortality, cardiovascular mortality and myocardial infarction, have shown significant association between age at menopause and cardiovascular outcomes [ 4, 5, 17, 18].
For each Spanish province, we estimated the peak timing of pandemic mortality defined as the month with maximal mortality elevation during the pandemic period.
The following information was extracted from each trial: first author, year of publication, number of patients (GDT and control), study population, clinical setting, goals in GDT and control groups, timing of GDT, mortality endpoint, study design (patient selection and concealment) and outcome data (overall mortality and dobutamine use).
They found that changes in the rate of spread and the timing of peak mortality each year correlated with yearly fluctuations in monthly airline passenger volume.
Brownstein et al. [2] analyzed the spread of influenza in the United States for 9 years (1996 2005) using signal processing methods, and found that domestic air travel volume predicted the rate of influenza spread, and international air travel affected the timing of influenza mortality.
Prior studies have not as precisely considered the timing of early mortality of infected infants [ 19, 20] nor separated IU transmission from IP/ePP transmission [ 21].
Our study's retrospective design, differences in patient selection across time periods, lack of information about ICU structure, process and use of disease-specific treatments, also make it impossible to assess the reasons for and timing of these mortality decreases.
