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The timing of exposure ascertainment relative to prostate cancer diagnosis or study entry was unclear for the remaining study subjects.
There may well be a threshold for both dose and timing of exposure that may affect male pubertal development.
Thus, the observed 4-day time lag in our study is consistent with the expected timing of exposure.
But some experts now think that the timing of exposure, rather than simply the dose, may be what matters.
Cortisol inhibition of placental cytokine production was dependent on timing of exposure, fetal sex and presence and absence of asthma.
We did not detect significant effect measure modification for timing of exposure.
[23] We therefore performed stratified analyses according to different timing of exposure and gender.
The hypothesis that timing of exposure may influence epigenetic mechanisms requires further investigation.
It is possible that the different timing of exposure affects different developmental stages in the brain.
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The findings demonstrated the value of categorizing timing of exposure to adversities as well as class membership.
To this end, we developed a questionnaire that focused on the exact type and timing of exposure to index patients.
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