Determining the timing of establishment helps us to understand the epidemiology of the invasion, that is, the rate and dynamics of the invasion process.
There is evidence for oocyte-size-dependent initiation and progression of methylation of maternal gDMRs, suggesting that different factors influence the timing of establishment of imprints at different loci (Lucifero et al., 2004; Hiura et al., 2006).
Overall, our observations support lineage-specific establishment of MAE and its stable maintenance in differentiated tissues, while the precise timing of MAE establishment may vary depending on genes and cell types.
The timing of methylation establishment of one DMR (FAM50B-DMR) has not yet been determined.
Subsequently we showed that a fibronectin- and laminin-containing ECM network develops coincidently with the timing of PCP establishment.
Therefore, it should not be discounted that there could be differences in mechanisms and perhaps timing of imprint establishment among mammals.
In addition, there is another classification, gametic DMRs and somatic DMRs, based on the timing of the establishment of differential methylation.
In addition, the timing of the establishment of a lineage-restriction boundary between the mesencephalon (the embryonic midbrain) and rhombomere 1 of the hindbrain has been determined using GIFM [ 6].
The inferred timings of the establishment of the two haplotypes are accurate, with the mutant in the red population being predicted to establish after 111 generations (real time 106 generations), and in the blue population mutants being predicted to establish after 94 and 426 generations (real times 83 and 429 generations).
Taken together, these results indicate that nephrocystins-1 and -4 are required for the proper timing of tight junctional establishment necessary for the formation of a fully polarized epithelial monolayer.
However, the precision of these age estimates is limited, as they are only based on linear interpolation between two dates, the lowest of which has a spread of calibrated age ranges spanning 75 years, therefore we use the historical evidence to refine the timing of O. lyallii establishment at Erebus Cove.
