The timing of decreased miR-295 expression is consistent with a previous report that showed miR-295 suppressed autophagic cell death [ 69]: miR-295 down-regulation in HVC during LDW may permit the concurrent increase in HVC cell death.
Suspicion of HIT was based on the 4T score: (a) a more than 50% decrease in platelet count after exposure to heparin, (b) timing of the decrease in platelet count compatible with HIT, (c) a new thrombosis, skin necrosis, or an acute systemic reaction after heparin administration, and (d) absence of other causes of thrombocytopenia [ 6].
By "precise timing of concentration decrease", we mean two features: i) starting from the time the kinase concentration increases, there is no appreciable change in the substrate concentration until a critical moment (i.e. temporal thresholding), and ii) the substrate concentration decreases immediately after passing the temporal threshold.
The perishing of the tubeworm colonies began in 1995 and coincided with the timing of energy decrease for sulfide oxidizers.
Second, the timing of the decrease coincides with a plateau in mammography use as measured by national surveys.
However, previous investigations also have shown that the timing of BMD decrease may be associated with the dose level of smoke exposure.
Thus, we considered that the timing of BMD decrease may be associated with the dose level and the duration of smoke exposure.
The timing of the decrease corresponded to changes in treatment guidelines from monotherapy with third-generation cephalosporins to combination therapy with ceftriaxone/azithromycin.
The exact mechanisms and timing of such decrease are however still unknown – the gene loss or pseudogenization could have occurred in large-genome Genlisea ancestor, and small-genome Genlisea lineage could have lost pseudogenes and other non-coding genome segments.
The timing of the decrease in pAkt levels (2 days after culturing at high insulin concentrations), which occurred 1 to 2 days before evident cell death of hNSC (3 5 days after culturing with high insulin concentrations, Figures 1 and 2), suggests that decreased Akt activation may mediate the observed cell death of hNSCs cultured at high insulin concentrations.
