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While the expression of a neurochemical phenotype occurs sometime after a given neuron's birth, the tight association between the time of cell cycle exit and neurochemical phenotypes suggests that the timing of cell cycle exit may control some aspect of neurochemical fate.
tmRNA also has a regulatory role for the correct timing of cell cycle regulation of C. crescentus [16].
The sgo1-100 and sgo1-700 mutations do not affect the timing of cell cycle entry.
The data (Additional file 1: Figure S1) confirmed synchronization after accounting for a shift in the timing of cell cycle events.
Dap is a member of the p21/p27 family of Cdk inhibitors, and is required during Drosophila embryogenesis for proper timing of cell cycle exit at G1 (de Nooij et al., 1996; Lane et al., 1996).
Checkpoint control creates a dependency between the mechanical aspects of cell division the complex physical interaction of chromosomes with the mitotic spindle and the timing of cell cycle progression.
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Data for the cell cycle specific expression of these yeast genes was determined by high-resolution timing of cell cycle-regulated gene expression based on genome-wide gene expression data of synchronized yeast cultures (Rowicka et al., 2007).
Knowing the joint marker status of each cell would permit the modeling of markers as a multivariate binomial random variable, and thus allow us to assess correlations between the presence of different markers, which might be particularly important when studying various kinds of mutant strains in which the timings of cell cycle events have been disrupted or shuffled.
Two important checkpoints (G1/S and G2/M) coordinate CDKs activity and control the order and timing of cell-cycle transitions ensuring that DNA replication and chromosome segregation are completed correctly before allowing further progress through the cycle.
A study by Bjarnason et al. [ 39] found correlation with the timing of circadian clock gene expression in oral mucosa and the timing of S phase of the cell cycle, suggesting that the circadian clock may control the timing of cell-cycle events in tissues.
Similarly, ovum manipulation leads to delayed progression of the female pronucleus [11] or, more likely, of cell cycle timing [12].
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Justyna Jupowicz-Kozak
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