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This was a single blind, randomized pilot study to determine feasibility (i.e., the ability of patients to undertake and complete the program as designed) and to assess appropriate outcomes and timing of assessment.
Study quality is also variable: some offer limited detail on assessment1, 7, 23, on case selection procedures1 and on timing of assessment in relation to outcome1.
Unlike recent work (Phipps et al, 2016), snoring did not alter the relationship of short sleep duration with mortality, which could be related to the timing of assessment (pre- vs post-cancer diagnosis).
The lack of standardization of specific cognitive tests and timing of assessment of cognitive function after CAS and CEA do not allow for definite conclusions to be drawn.
A definitive conclusion regarding the effect of CAS versus CEA on cognitive function was not possible owing to heterogeneity in definition, method, timing of assessment, and type of cognitive tests.
Green RE, Colella B, Hebert DA, Bayley M, Kang HS, Till C, Monette G. Prediction of return to productivity after severe traumatic brain injury: investigations of optimal neuropsychological tests and timing of assessment.
Significant heterogeneity remains in the initial inclusion criteria, staging and restaging methods, study design, timing of assessment, duration and rigour of follow-up of the trials reviewed — all of which obscure the validity of the results.
Some of the discrepancies may be explained, at least in part, by differences in the health care system and procedural aspects (e.g. timing of assessment).
BACKGROUND: Although most clinical trials of coronary stents have measured nominally identical safety and effectiveness end points, differences in definitions and timing of assessment have created confusion in interpretation.
During our reviewing and writing process, we received several comments about timing of assessment from TCA-SIG reviewers, arguing that TA could be done at any time of the life cycle of a PRO measure.
The limited number of cases per age group in the reviewed studies is further complicated by the heterogeneity in the range of BD subtypes included and timing of assessment of symptoms.
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