Among 86 protocols for randomised trials with a time-to-event cancer outcome that proposed efficacy interim analyses, all stated the planned timing of the analyses, 91% specified the overall reason to be used for stopping (eg, superiority, futility), and 94% detailed the statistical approach.
Modified NRI was used to assess DAS28 ESR) low disease activity (LDA) and DAS28 ESR) remission for timing of response analyses.
Missing data were thought to occur at random given the timing of our analyses immediately after trial enrollment; thus, patients with missing data were excluded from analysis.
Since there were no differences between cases and controls in frequency or timing of exposure, analyses are restricted to children to mothers exposed to prenatal X-ray, regardless of numbers of examinations or time of exposure.
A good method will have high DR and low FPR, and these parameters could be examined in relation to trial size, the timing of interim analyses, and different statistical methods.
134 Item 7b of the checklist requires the reporting of timing of interim analyses, what triggered them, how many took place, whether these were planned or ad hoc, and whether there were statistical guidelines and stopping rules in place a priori.
In addition, our results highlight the rapidity of HIV-1 env evolution and the importance of sample timing in analyses of gene flow.
To determine the effect of timing of treatment we analysed the different subgroups of patients treated with aspirin (aspirin pre-ICU, aspirin pre-ICU and in ICU, aspirin in ICU only) and those never treated with aspirin.
This may be due to differences in eligibility criteria, non-sensitive literature searches, differences in timing of the meta-analyses (more recent papers would include more trials), or other reasons.
This study shows that timing of exposure and restricting analyses to more homogeneous endpoints are important in characterizing the reproductive toxicity of pesticides.
