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In the present study, we utilized a mouse model of leukemogenesis to identify epigenetically altered genomic loci on a global scale and to determine the timing of altered epigenetic reprogramming.
However, little is known about the timing of altered brain development and its occurrence in specific congenital heart disease subgroups.
Several factors can affect the direction of miRNA expression changes in CLL cells and activated B cells including the timing of altered miRNA expression, type of stimulation, or that certain changes may be important to the pathobiology of CLL.
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An independent time-course experiment confirmed these results and excluded the possibility of altered transcriptional timing and/or transcript accumulation in 3D7/pBC4 parasites (Fig. S2).
For example, we find that differences in the timing of events altering leaf vascular development and BS chloroplast division occur prior to the appearance of the alternative evolutionary pathways generating the NADP-ME and NAD-ME biochemical sub-types.
However, it is far more likely that, as previously observed in T7 phage, genes with no direct role in cell lysis affect lysis timing by altering timing of lysis gene expression or by indirect effects on other stages of the life cycle rather than lysis mechanisms per se [ 17, 20, 49].
When methylated xanthines were administered to the laboratory animals in active phase (human "morning), as if they had a cup of black coffee, their body clocks' timing returned to that of an earlier time of day... when [they] were given toward the evening hours, once again there was a dramatic reaction, only this time the body clocks' timing altered to that of a much later hour.
To assess the effect of altering the timing of hCG administration on ongoing pregnancy rates in patients stimulated with recombinant FSH (rec-FSH) and GnRH antagonists for IVF.
The effects of altering the timing of recombinant human granulocyte colony-stimulating factor (rhG-CSF) administration on neutropenia induced by cyclophosphamide (CPA) were studied experimentally in a mouse model.
Our data revealed a correlation between origin structure and replication timing and we therefore wondered whether histone acetylation might modify replication timing by altering the chromatin architecture of replication origins.
Even in the non-neurosurgical critical care population, there is insufficient and conflicting evidence regarding whether the timing of tracheostomy alters the duration of mechanical ventilation or extent of airway injury [ 21].
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