This mechanism is backwards compatible and incrementally deployable, and takes into account the timing limitations of existing hardware, as well as practical CSMA-related issues (e.g., capture effect).
Complaining about its timing, its limitations or its alleged political motivation does not and should not demean its importance and the humanity it offers.
The delay to thaw and initiate FFP transfusion leads to another important limitation: timing to initiate and reach the high FFP RBC ratio.
Limitation on timing of tissue procurement.
However, this limitation in timing allowed us to provide a descriptive comparison of the immediate effects of the dosing regimens.
Past studies examining environmental determinants of pubertal timing have exhibited methodological limitations.
We expect that the limitations regarding timing will gradually be resolved in the future, since Web browsers develop very rapidly with a focus on speed.
We discussed with couples the benefits, limitations and timing for result delivery in routine analysis (karyotype and QF-PCR), as well as the possibility to extend prenatal studies with additional analysis (MLPA and CMA) with the a priori benefits, limitations and timing of those studies.
In order to provide an effective vaccine against S. aureus, a number of unresolved issues in vaccine development relating to optimal antigenic target identification, criteria for acceptable efficacy, identification of target population, commercial development limitations, optimal timing of immunization strategy, storage, cold chain requirements and cost need to be addressed properly.
Additionally, there are issues relating to optimal antigenic target identification, criteria for acceptable efficacy, identification of the target population in children as well as adults, commercial development limitations, optimal timing of immunization strategy, storage and cold chain requirements, cost of development and cost effectiveness (64).
